Which of the following is not quantified in the triple test for Down syndrome?

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Multiple Choice

Which of the following is not quantified in the triple test for Down syndrome?

Explanation:
This question tests which maternal serum markers are used in the Down syndrome screening panel in the second trimester. The triple test measures three specific analytes: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol (uE3). In pregnancies affected by Down syndrome, AFP and uE3 typically fall, while hCG rises, creating a characteristic pattern that prompts further testing if abnormal. Progesterone, though important in pregnancy for other reasons, is not part of this screening panel. In the later quadruple test, inhibin A is added to the three markers, but progesterone still isn’t included. So the marker not quantified in the triple test is progesterone.

This question tests which maternal serum markers are used in the Down syndrome screening panel in the second trimester. The triple test measures three specific analytes: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol (uE3). In pregnancies affected by Down syndrome, AFP and uE3 typically fall, while hCG rises, creating a characteristic pattern that prompts further testing if abnormal. Progesterone, though important in pregnancy for other reasons, is not part of this screening panel. In the later quadruple test, inhibin A is added to the three markers, but progesterone still isn’t included. So the marker not quantified in the triple test is progesterone.

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