Estriol is produced in the placenta from a fetal precursor called 16α-Hydroxy-DHEA-S formed in the _____.

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Enhance your knowledge with the Ciulla Clinical Chemistry Test. Study with interactive quizzes, featuring flashcards and multiple-choice questions. Each question offers hints and explanations for better understanding. Prepare effectively and excel in your exam!

Multiple Choice

Estriol is produced in the placenta from a fetal precursor called 16α-Hydroxy-DHEA-S formed in the _____.

Explanation:
Estriol production during pregnancy relies on fetal steroid precursors. The placenta cannot make estrogens from cholesterol on its own and uses a fetal product, 16α-hydroxy-DHEA-S, formed in the fetus (primarily by fetal adrenal/letal contributions). The placenta then converts this fetal compound into estriol, which enters maternal circulation. This fetal origin of the precursor explains why the fetus is the correct source.

Estriol production during pregnancy relies on fetal steroid precursors. The placenta cannot make estrogens from cholesterol on its own and uses a fetal product, 16α-hydroxy-DHEA-S, formed in the fetus (primarily by fetal adrenal/letal contributions). The placenta then converts this fetal compound into estriol, which enters maternal circulation. This fetal origin of the precursor explains why the fetus is the correct source.

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