Cerebrospinal fluid glucose is typically approximately what percentage of plasma glucose?

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Enhance your knowledge with the Ciulla Clinical Chemistry Test. Study with interactive quizzes, featuring flashcards and multiple-choice questions. Each question offers hints and explanations for better understanding. Prepare effectively and excel in your exam!

Multiple Choice

Cerebrospinal fluid glucose is typically approximately what percentage of plasma glucose?

Explanation:
CSF glucose reflects plasma glucose because glucose crosses into the CSF by facilitated diffusion across the blood-brain barrier, mainly via GLUT1 transporters, and brain tissue consumes some of the glucose as well. In healthy individuals, the CSF glucose level is typically about 60% of the plasma level. For example, if plasma glucose is 5.0 mmol/L, CSF glucose is usually around 3.0 mmol/L. The ~60% relationship arises from diffusion-limited transport and ongoing cerebral utilization. Values around 30% would imply unusually low transport or high consumption, while 90% or more would not align with how glucose moves into CSF.

CSF glucose reflects plasma glucose because glucose crosses into the CSF by facilitated diffusion across the blood-brain barrier, mainly via GLUT1 transporters, and brain tissue consumes some of the glucose as well. In healthy individuals, the CSF glucose level is typically about 60% of the plasma level. For example, if plasma glucose is 5.0 mmol/L, CSF glucose is usually around 3.0 mmol/L. The ~60% relationship arises from diffusion-limited transport and ongoing cerebral utilization. Values around 30% would imply unusually low transport or high consumption, while 90% or more would not align with how glucose moves into CSF.

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